Role of hepatocyte growth factor in diagnosing and predicting recurrence of stroke

Objective To research whether serum hepatocyte growth factor (HGF) level increases in ischemic stroke and hemorrhagic stroke, and explore the relationship between the serum HGF level and stroke recurrence. Methods We studied a total of 92 consecutive acute stroke patients who had been admitted to hospital within 24?h of onset from 6 participating hospitals in Xi'an from January 2000 to May 2004. All patients were divided into ischemic stroke group and hemorrhagic stroke group according to the results of brain computed tomography (CT) scan or MRI on admission. Patients in stroke groups were divided into recurrent group and non-recurrent group. Healthy volunteers or patients without cerebrovascular diseases comprised the control group. Stroke and control groups were strictly matched with 1∶1 ratio. The patients were followed up for 4 years. Serum HGF was tested with enzyme-linked immunosorbent assay (ELISA). Results Serum HGF of stroke patients was significantly higher than that of control group (P<0.05). The serum HGF level in recurrent group was higher than that in non-recurrent group of ischemic patients, and there was no significant difference in hemorrhagic ones. Conclusion These results indicate that serum HGF may be used as a diagnostic marker for stroke, and serum HGF level is helpful in predicting the recurrence of ischemic stroke.

作 者： Xue Wang Hua Qiang Li-Na Wang Ai-Qun Ma   作者單位： The First Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an 710061, China  刊 名： 西安交通大學學報（英文版）  英文刊名： ACADEMIC JOURNAL OF XI'AN JIAOTONG UNIVERSITY(ENGLISH EDITION)  年，卷(期)： 2010 22(1)  分類號： U4  關(guān)鍵詞： hepatocyte growth factor   stroke   recurrence  

【Role of hepatocyte growth factor in 】相關(guān)文章：

Heighten the Study on Factor Seven Activating Protease04-27

Sowing the Seeds, Nurturing Growth and Harvesting05-04

Progress in modeling of fluid flows in crystal growth processes04-26

Effects of nutrients on Microcystis growth more easily forming bloom04-25

Grotesques Loneliness and Georges Growth In Winesburg, Ohio by Sherwood Anderson04-27

Growth and phosphate uptake kinetics of Microcystis aeruginosa under various environmental conditions04-26

An evaluation of the role played by remote sensing technology following the World Trade Center attack04-27

15 CASC-Made Satellites Play Important Role In Sichuan Earthquake Relief04-26

大學英語作文：國內(nèi)生產(chǎn)總值增長 The GDP Growth of Country08-09

Species diversity and regeneration of old-growth seasonally dry Shorea robusta forests following gap formation04-26